日本九州大学基本概况

　　三、教研优势

　　1.重点研究领域

　　International Institute for Carbon-Neutral Energy Research  (I2CNER),Innovation Center for Medical Redox NavigationHydrogen Energy  Research,World-Leading Hydrogen Energy Research,Interntional Research Center for  Hydrogen Energy,Research Center for Hydrogen Energy Industrial Use and  Storage,Next-Generation Fuel Cell Research Center (NEXT-FC),Center for  Co-Evolutional Social Systems,Center for Clinical and Translational Research  (CCTR),Hisayama Study,JST-ERATO ADACHI Molecular Exciton Engineering  Project.

　　国际碳中和能源研究所(I 2  CNER)、医疗氧化还原导航创新中心、氢能研究、世界领先的氢能研究、国际氢能研究中心、氢能工业利用与储存研究中心、下一代燃料电池研究中心(NEXT-FC)、共同社会系统中心、临床与转化研究中心(CCTR)、久山研究、ST-ERATO  ADACHI分子激子工程项目。

　　2.杰出研究成果展示

　　Liquid crystals swirl; Theory and experiments reveal new ordered structures  of a liquid crystal

　　Liquid crystals, now found everywhere in flat TVs and mobile phones, are  also an important research subject of physics, because they spontaneously form  various ordered structures. Prof. Jun-ichi Fukuda at Kyushu University (formerly  at National Institute of Advanced Industrial Science and Technology (AIST)), in  collaboration with researchers at National Academy of Science (Ukraine),  University of Ljubljana and Jožef Stefan Institute (Slovenia), showed for the  first time, both theoretically and experimentally, that swirl-like structures  known as half-Skyrmions (Fig.1) are spontaneously formed in a thin film of a  liquid crystal.Skyrmions, swirl-like vectorial order without singularities, have  been known to emerge in diverse condensed matter systems, and particularly those  in ferromagnets have been attracting growing attention. The research group of  Prof. Fukuda previously showed the possibility of the formation of  half-Skyrmions (Fig.1) in a thin film of a liquid crystal theoretically, and the  present research experimentally demonstrated their formation by optical  microscope observations (the size of a half-Skyrmion was a few hundred  nanometers, close to the resolution limit of optical microscopy). Theoretical  calculations on the ordered structures of a liquid crystal, and their resulting  optical microscope images corroborated the experimental observations. It was  also shown that half-Skyrmions not only form a regular lattice but also can  exist as isolated entities (Fig.1).These results in the present study show novel  features of liquid crystals as structural and optical materials, and the  theoretical calculations in the research extend the possibility of optical  microscopy for the observation of submicron-scale objects.

　　研究成果一：液晶漩涡; 理论和实验揭示了液晶的新有序结构

　　现在在平板电视和手机中发现的液晶也是物理学的重要研究课题，因为它们自发形成各种有序结构。九州大学(日前在国立先进工业科技研究所(AIST))的福田淳一教授与国立科学院(乌克兰)，卢布尔雅那大学和JožefStefan研究所(斯洛文尼亚)的研究人员合作，展示了在理论上和实验上，首次在液晶的薄膜中自发形成被称为半载体(图1)的漩涡状结构。众所周知，具有不同奇异性的漩涡般的矢量秩序在不同凝聚物体系中出现，特别是铁磁体中的那些已经引起越来越多的关注。Fukuda教授的研究小组以前在理论上表现出在液晶薄膜中形成半晶格(图1)的可能性，本研究通过光学显微镜观察(其尺寸为半数Skyrmion是几百纳米，接近光学显微镜的分辨率极限)。对液晶有序结构的理论计算及其所得的光学显微镜图像证实了实验观察结果。本研究的结果表明液晶作为结构和光学材料的新特征，研究中的理论计算扩展了光学显微镜观察亚微米级物体的可能性。

　　TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of  hyperglycemia-induced heart failure in mice

　　The research groups led by Professor Nishida of Kyushu University, here  demonstrated that deletion of TRPC6 had no impact on pressure overload-induced  heart failure despite inhibiting interstitial fibrosis in mice. TRPC6-deficient  mouse hearts 1 week after transverse aortic constriction showed comparable  increases in fibrotic gene expressions and ROS production but promoted  inductions of inflammatory cytokines, compared to wild type hearts. Treatment of  TRPC6-deficient mice with streptozotocin caused severe reduction of cardiac  contractility with enhancing urinary and cardiac lipid peroxide levels, compared  to wild type and TRPC3-deficient mice. Knockdown of TRPC6, but not TRPC3,  enhanced basal expression levels of cytokines in rat cardiomyocytes. TRPC6 could  interact with Nox2, but the abundance of TRPC6 was inversely correlated with  that of Nox2. These results strongly suggest that Nox2 destabilization through  disrupting TRPC3-Nox2 complex underlies attenuation of hyperglycemia-induced  heart failure by TRPC6.This research achievement was published online in  Scientific Reports on August 8, 2017, 18.

　　研究成果二：TRPC6抵抗TRPC3-Nox2蛋白复合物，导致小鼠中高血糖诱导的心力衰竭的衰减

　　由九州大学Nishida教授领导的研究小组证实，尽管抑制小鼠间质性纤维化，TRPC6的缺失也不会对压力过载引起的心力衰竭产生影响。与野生型心脏相比，横向主动脉收缩后1周的TRPC6缺陷小鼠心脏纤维化基因表达和ROS产生显示出可比的增加，但促进炎性细胞因子的诱导。与野生型和TRPC3缺陷小鼠相比，用链脲佐菌素治疗TRPC6缺陷小鼠引起心肌收缩力的严重降低，同时增强尿和心脏脂质过氧化物水平。敲除TRPC6而不是TRPC3，增强大鼠心肌细胞中细胞因子的基础表达水平。TRPC6可以与Nox2进行交互，但TRPC6的丰度与Nox2呈负相关。这些结果强烈地表明，通过破坏TRPC3-Nox2复合物的Nox2不稳定性是TRPC6对高血糖诱导的心力衰竭衰减的基础。该研究成果于2017年8月8日18日在“科学报告”上发表。

　　A new synthesis route for alternative catalysts of noble metals

　　Researchers have developed a new synthesis route for alternative catalysts  of noble metals for versatile chemical reactions that could help address  environmental concerns.Noble metals such as platinum are useful as catalysts for  versatile chemical reactions including fuel cell vehicles and reduction of CO2  emission. However, they are costly to be used for these purposes.As inexpensive  alternatives, organic-based catalysts and carbonaceous catalysts were explored,  but both were ultimately found to be impractical. This was because organic-based  catalysts tend to be active but unstable, while carbonaceous catalysts are  stable but less active.In this work, researchers believe to have found a  solution by developing a new synthesis route for intermediate materials of  organic-based catalysts and carbonaceous catalysts.While conventional  carbonaceous catalysts have amorphous carbonaceous structures that cause a  decline in catalytic activities (Fig. 1a), the new synthesis route enables the  formation of carbonaceous catalysts with controlled chemical structures like  organic-based catalysts (Fig. 1b). This synthesis route is capable of developing  alternative catalysts of noble metals for many eco-friendly technologies such as  fuel cell vehicles, hydrogen generation from water and CO2 reduction.“Network  Joint Research Center for Materials and Devices” is a center to deepen and  create new framework for the collaborative research among five different  research institutes. This research was conducted through the “Five-Star Alliance  research program” of the research center.

　　研究成果三：贵金属替代催化剂的新合成路线

　　研究人员开发了一种新的合成途径，用于贵金属的替代催化剂，用于多种化学反应，可以帮助解决环境问题。贵金属如铂可用作多种化学反应的催化剂，包括燃料电池车辆和减少二氧化碳排放。然而，它们用于这些目的是昂贵的。作为廉价的替代品，探索了有机基催化剂和碳质催化剂，但是最终都被认为是不切实际的。这是因为有机基催化剂倾向于具有活性但不稳定，而碳质催化剂稳定但活性较低。在这项工作中，研究人员相信通过为有机催化剂和碳质催化剂的中间体材料开发新的合成途径找到了一个解决方案。虽然传统的碳质催化剂具有导致催化活性下降的无定形碳质结构(图1a)，但新的合成路线使得能够形成具有受控化学结构的碳质催化剂，如有机基催化剂(图1b)。这种合成路线能够为许多环保技术开发贵金属的替代催化剂，例如燃料电池车辆，来自水和二氧化碳还原的氢气产生。“材料与器件网络联合研究中心”是深化和建立五个研究机构合作研究新框架的中心。这项研究是通过研究中心的“五星级联盟研究计划”进行的。

　　New therapeutic strategy for metformin-associated lactic acidosis  (MALA)

　　- Targeting oxygen sensor PHD for lactic acidosis treatment -Metformin is  one of the most widely used therapeutics for type 2 diabetes mellitus and also  has anti-cancer and anti-aging properties. However, it is known to induce  metformin-associated lactic acidosis (MALA), a severe medical condition with  poor prognosis, especially in individuals with renal dysfunction. Inhibition of  oxygen sensing prolyl hydroxylase (PHD) is known to activate transcription  factor HIF (hypoxia-inducible factor) that increases lactate efflux as a result  of enhanced glycolysis, but it also enhances gluconeogenesis from lactate in the  liver that contributes to reducing circulating lactate levels. Here the research  group of Kyushu University, Keio University School of Medicine and Daiichi  Sankyo Co., Ltd. investigated the outcome of pharmaceutical inhibition of PHD in  mice with MALA induced through the administration of metformin per os and an  intraperitoneal injection of lactic acid. We found that the PHD inhibitors  significantly increased the expression levels of genes involved in  gluconeogenesis in the liver and the kidney, and significantly improved the  survival of mice with MALA. Furthermore, the PHD inhibitor also improved the  survival rate of MALA aroused on chronic kidney disease (CKD) mice. Thus, PHD  represents a new therapeutic target for MALA, which is a critical complication  of metformin therapy.

　　研究成果四：二甲双胍相关性乳酸性酸中毒(MALA)的新治疗策略

　　- 乳酸酸中毒治疗靶向氧传感器PHD  -二甲双胍是2型糖尿病最广泛使用的治疗剂之一，也具有抗癌和抗衰老的功能。然而，已知诱导二甲双胍相关的乳酸性酸中毒(MALA)是一种严重的预后不良的医疗状况，特别是在具有肾功能障碍的个体中。氧传感脯氨酰羟化酶(PHD)的抑制作用是通过增强糖酵解来激活转录因子HIF(缺氧诱导因子)，其增加乳酸流出，但也增强了肝脏中从乳酸中促进糖异生作用，有助于降低循环乳酸水平。这里是九州大学，庆应大学医学院和第一三共有限公司的研究小组  研究了通过给予二甲双胍和口服乳酸诱导的MALA小鼠中PHD药物抑制的结果。我们发现PHD抑制剂显着增加了参与肝脏和肾脏糖异生的基因的表达水平，并显着改善了MALA小鼠的存活率。此外，PHD抑制剂还改善了慢性肾脏疾病(CKD)小鼠引起的MALA的存活率。因此，PHD代表了MALA的新治疗靶标，其是二甲双胍治疗的关键并发症。并显着改善了具有MALA的小鼠的存活。此外，PHD抑制剂还改善了慢性肾脏疾病(CKD)小鼠引起的MALA的存活率。因此，PHD代表了MALA的新治疗靶标，其是二甲双胍治疗的关键并发症。并显着改善了具有MALA的小鼠的存活。此外，PHD抑制剂还改善了慢性肾脏疾病(CKD)小鼠引起的MALA的存活率。因此，PHD代表了MALA的新治疗靶标，其是二甲双胍治疗的关键并发症。

　　四、校园环境

　　1.　校园生活

　　Campus Life

　　Dormitories：Campus Dormitory Features/Providing an international  environment within the dormitories/Creating communities via multinational  leaders.The dormitories at the Ito Campus are international dormitories where  students from several different countries live together. A diverse mixture of  students, from freshman to graduate school students (both master's and doctoral  course candidates), live together in these dormitories.Distinguishing them from  other college dormitories that feature strict rules and hierarchies, here at the  Ito Campus dormitories, we respect your private life and take measures into  consideration that allow you to build human relationships and interact with  other diverse students.For that reason, we assign students who have experience  living in the dormitories as dormitory leaders, so they become the nucleus of  student interaction.These dormitory leaders will not only help you out when you  first move in, but will also give you advice on everyday life, so those living  on their own for the first time can do so with peace of mind.

　　Dormitory 1

　　Features:This dormitory is located at the center of campus and features a  1:1 ratio of international and Japanese students. (All rooms are  individual).10-story, iron-reinforced concrete building,252 13m2 single rooms,2  26m2 rooms for physically disabled students.Targeted Students: Male and female  graduate students (including international students),5 minute walk.

　　Dormitory 2

　　Features:This dormitory is located at the center of campus and features an  8:2 individual ratio of Japanese to international students. (All rooms are  individual) Within the international dormitories, this is the one with the  highest percentage of Japanese studentsm10-story, iron-reinforced concrete  building,248 17m2 single rooms,26 43m2 or 48m2 rooms for married  couples,Targeted Students: Male and female graduate students (including  international students) , Married international students,5 minute walk.

　　Dormitory 3

　　Features:This dormitory is located at the center of campus and features  shared rooms that consist of 4 people per unit. They are organized into 2  international students and 2 Japanese students per unit. Living spaces are  private, so they provide a moderate amount of privacy. The toilet, bath,  kitchen, and dining room are shared between 4 people. Students who wish to live  in a dense, communal environment in order to maximize their chances for  international exchange, are selected for these units.5-story, iron-reinforced  concrete building.Shared rooms for 136 people (34 units X 4 people).Private  space: 4 X 7m2 rooms.Shared space: 28mTargeted Students: Male and female  undergraduates, male and female graduate students.5 minute walk

　　Harmony House:This dormitory is located approximately 1km from the center  of campus and features the largest amount of living spaces at the university  with 581 rooms. We have established a 1:1 ratio between Japanese and  international students in regards to individual rooms, so we are able to provide  an environment where you can interact with international students on a daily  basis.9-story, iron-reinforced concrete building for individual  students.6-story, iron-reinforced concrete building for married couples.17㎡-551  17m2 single rooms / 30 rooms for married couples.Targeted Students: Male and  female undergraduates, male and female graduate students , Married international  students.15 minute walk.

　　2.宿舍

　　校园宿舍特色

　　通过多国领导人在宿舍或者创建社区中提供的国际环境，伊藤校区的宿舍是来自不同国家的学生住在一起的国际宿舍。从大一新生到研究生学生(硕士和博士生候选人)的不同的学生混合在一起住在这些宿舍。我们尊重您的私人生活，并采取措施，让您建立人际关系并与其他不同学生进行互动，与其他具有严格规则和等级制的大学宿舍区分开来。因此，我们将生活在宿舍的经验指派为宿舍领导，成为学生互动的核心。这些宿舍领导人不但可以帮助您，而且还会为您提供日常生活中的建议，让自己第一次生活的人能够安心。

　　宿舍1

　　特色：该宿舍位于校园中心，比例为1：1的国际和日本学生。(所有房间都是独立的)，10层钢铁混凝土建筑，25213平方米单人间，226平方米有行动障碍的学生客房，有针对性的学生：男女研究生(含国际学生)，步行5分钟。

　　宿舍2

　　特点：该宿舍位于校园中心，日语与国际学生的个人比例为8：2。(所有房间均为个人)在国际宿舍内，这是日本学生比例最高的宿舍。10层钢铁混凝土建筑，24817平方米单人房，2643平方米或48平方米的已婚夫妇房间，有针对性的学生：男女研究生(含国际学生)，已婚国际学生，步行5分钟。

　　宿舍3

　　特点：该宿舍位于校园中心，设有共享客房，每间客房4人。他们每个单位组织成2名国际学生和2名日本学生。生活空间是私人的，所以他们提供适度的隐私。厕所，浴室，厨房和餐厅由4人共用。希望在密集的社区环境中生活，以最大限度地发挥国际交流的机会的学生被选为这些单位。五层钢铁混凝土建筑，共136人(34单位×4人)，私人空间：4  X 7平方米房间，共享空间：28平方米，目标学生：男，女大学生，男女研究生，步行5分钟。

　　伊藤和谐之家

　　这个宿舍距离校园中心约1公里，大学生活空间最大，有581间客房。我们在日本和国际学生之间建立了1：1的个人房间比例，所以我们能够提供一个环境，让您每天都能与国际学生互动。宿舍一共9层，钢筋混凝土的建筑是为个别学生。6层，已婚夫妇的钢筋混凝土建筑，17㎡-551  17平方米单人间/已婚夫妇30间宿舍可以供你选择，有针对性的学生：男女本科生，男女研究生，已婚国际学生，步行15分钟。

　　2.饮食情况及校内设施

　　自助餐厅(九州大学合作社)

　　书店/商店(九州大学合作社)

　　自助餐馆

　　书店/商店

　　菊池校区，建立了菊池校区(维多利亚大厅)的福利设施，以促进课外活动，为学生和教师提供福利，所以在大楼里设有一个自助餐厅、咖啡厅、书店、固定店食堂或者商店等。

　　大桥校区 食堂/商店

　　伊藤校区，大叶有一个自助餐厅，商店和咖啡厅。(星期六和星期日也开放)。咖啡厅，商店，咖啡厅和私人设施(汉堡包店)

　　大多拉有一个自助餐厅，商店和咖啡厅。(星期六和星期日也开放)，自助餐厅/咖啡馆/店/书店

　　西区2号Piloti有一家商店(周六和周日也开放)

　　演讲厅西部有咖啡厅(E-cafe)。

　　咖啡店

　　在Kokosha有一家书店和商店。(星期六和星期日也开放)，书店/商店

　　3.相关服务

　　Regular Medical Checkup：Every April regular medical checkups for all  students are conduct. If any problems are discovered, in addition to  implementing retests (re-measurements) or detailed examinations, treatment or  consultations by specialists will be recommended if necessary.Notification of  Regular Medical Checkup，Special Regular Medical Checkup，For those students or  recombinant DNA researchers who--for experimentation and practical  training--handle radioactive isotopes, radiation generators, X-ray generators  (including electron microscopes over 100 kV accelerating voltage), nuclear fuel  materials, nuclear source materials, etc., we are conducting examinations and  medical histories in locations such as the Radiation Damage Prevention Blood  Testing Room.Medical checkup certificates required for university scholarship  applications or job applications will be based on records from the periodic  medical checkup. Those who do not get this examination cannot be issued a  certificate. The medical examination certificate can be obtained at the  automatic certificate issuing machine or Health Science Center (any campus's  Health Consultation Room) located on each campus.

　　体格检查：定期体检，所有学生每4月定期进行体检。如果发现任何问题，除了实施重新测试(重新测量)还是进行详细的检查之外，如有必要，我们建议您向专家进行治疗或咨询。特别定期体检，对于那些通过实验和实践训练处理放射性同位素，X射线发生器(包括超过100  kV加速电压的电子显微镜)，核燃料材料，核源材料等的学生或重组DNA研究人员，我们正在辐射防护血液检测室等场所进行检查和医疗史。相关信息，大学奖学金申请或工作申请所需的体检证明将根据定期体检的记录。没有得到这个考试的人不能颁发证书。体检证书可以在每个校园的自动证书签发机器或健康科学中心(任何校园健康咨询室)获得。

　　五、知名校友(源自网络)

　　郭沫若

　　桥本策(1881-1934)著名医学家，桥本氏甲状腺炎的发现者。

　　若田光一(1963- )宇航员，第一个进入太空的日本人。

　　以上内容由出国留学网www.liuxue86.com独家翻译，版权归出国留学网所有，未经出国留学网授权许可，任何公司任何人不得转载，违者必追究法律责任!

　　推荐阅读：

　　留学归来真的好就业吗?

　　高考成绩不理想，出国留学现实吗？

　　最受中国留学生亲睐的目的国和专业是什么